Bayer Enters Into Co-Development Agreement With Loxo Oncology

— Vitrakvi® was approved in November 2018 as the first TRK inhibitor for patients with advanced solid tumors with NTRK gene fusion; Bayer: Science For A Better LifeBayer is a global company with core skills in health and agriculture. Its products and services are intended to benefit citizens and improve their quality of life. At the same time, the group wants to create value through innovation, growth and high profitability. Bayer defends the principles of sustainable development and its social and ethical responsibility as a corporate citizen. In fiscal 2016, the group employed approximately 115,200 people and generated sales of 46.8 billion euros. Investments amounted to 2.6 billion euros and research and development expenditure to 4.7 billion euros. These figures include those of the high-tech polymer industry, which was launched on October 6, 2015 as an independent company called Covestro. For more information, see www.bayer.com. About Loxo OncologyLoxo Oncology is a biopharmaceutical company that innovates the development of highly selective drugs for patients with genetically defined cancers. Our pipeline focuses on cancers, which depend on individual genetic abnormalities in a unique way, so that a single drug has the potential to treat cancer with dramatic effects. We believe that the most selective drugs, specially designed for this purpose, are most likely to inhibit the objective as much as possible and thus guarantee a first-rate fight and safety.

Our management team is looking for experienced professional partners, first-class scientific consultants and innovative clinical and regulatory approaches to provide patients with new cancer therapies as quickly and efficiently as possible. For more information, please visit the company`s website at www.loxooncology.com. Documents submitted by Loxo after the announcement of the agreement with Lilly show that the clinical progress of LOXO-292 has pushed biotechnology to launch a broad network of potential pharmaceutical partners. After an intermediate reading, Loxo approached 15 biotechnology and pharmacy companies in April 2018. Initial discussions did not reveal any offers deemed attractive enough by Loxo, although negotiations with four companies continued until December. Results presented in October showed that treatment with LOXO-292 in 29 patients with ERT mutant thyroid cancer resulted in a response rate of nearly 60%, while previous data from a larger group showed a response rate of 77% in several types of tumors last June. Under the terms of the agreement, Loxo Oncology will receive a down payment of $400 million. Loxo Oncology is eligible for milestone payments of $450 million for larotrectinib authorities` approvals and early commercial events in certain major markets and an additional $200 million in milestone payments for LOXO-195 regulatory approvals and early commercial sales events in certain major markets. “While incidence rates are not high, the response rates [on LOXO-292] are truly remarkable, so we think we will see significant penetration and also a long lifespan of the reaction,” said Lilly`s new oncology manager, Anne White, in a recent profit call. — In its agreement with Loxo Oncology In agreement with Loxo Oncology Advise patienten und Betreuer n.V., Bayer used these risks with VITRAKVI to obtain full licensing rights for the two TRK inhibitors under a change-control clause. Patients are not advised to drive or operate dangerous machines if they have neurological side effects.

Depending on its degree of severity, do not hold vitrakvi or stop it permanently. If you are held, change the dose of VITRAKVI when you are taken back.

— bella.mark